Chronic infection with the hepatitis C virus (HCV) affects 170 million people worldwide and
is an important cause of liver-related morbidity and mortality. The standard of care therapy …

Cellular nucleotide pools are often contaminated by base analog nucleotides which interfere
with a plethora of biological reactions, from DNA and RNA synthesis to cellular signaling. An …

Inosine triphosphate pyrophosphatase (ITPase), encoded by the ITPA gene in humans, is an
important enzyme that preserves the integrity of cellular nucleotide pools by hydrolyzing the …

Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X),
hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and …

BACKGROUND & AIMS: In a genome-wide association study of patients being treated for
chronic hepatitis C, 2 functional variants in ITPA that cause inosine triphosphatase (ITPase) …

Background & Aims Genetic variation of inosine triphosphatase (ITPA) causing an
accumulation of inosine triphosphate (ITP) has been shown to protect patients against …

To characterize the genetic variation of alternative splicing, we develop GLiMMPS, a robust
statistical method for detecting splicing quantitative trait loci (sQTLs) from RNA-seq data …

Polymorphisms of the inosine triphosphatase (ITPA) gene influence anemia during
pegylated interferon (PEG‐IFN) and ribavirin (RBV) therapy, but their effects during triple …

Objective To identify the etiology of a novel, heritable encephalopathy in a small group of
patients. Methods Magnetic resonance imaging (MRI) pattern analysis was used to select …

Background Genetic factors can play an important role for treatment response and disease
progression in chronic viral hepatitis. Aim To review the influence of host genetic factors on …