Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis
MW Pitts, PR Hoffmann - Cell Calcium, 2018 - Elsevier
The human selenoprotein family contains 25 members that share the common feature of
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …
containing the amino acid, selenocysteine (Sec). Seven selenoproteins are localized to the …
System-wide pollution of biomedical data: consequence of the search for hub genes of hepatocellular carcinoma without spatiotemporal consideration
Biomedical institutions rely on data evaluation and are turning into data factories. Big-data
storage centers, supercomputing systems, and increased algorithmic efficiency allow us to …
storage centers, supercomputing systems, and increased algorithmic efficiency allow us to …
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer
Abstract Selenophosphate synthetase 2 (SEPHS2) synthesizes selenide and ATP into
selenophosphate, the selenium donor for selenocysteine (Sec), which is cotranslationally …
selenophosphate, the selenium donor for selenocysteine (Sec), which is cotranslationally …
Biochemical characterization of the selenoproteome in Gallus gallus via bioinformatics analysis: structure–function relationships and interactions of binding …
SY Zhu, XN Li, XC Sun, J Lin, W Li, C Zhang, JL Li - Metallomics, 2017 - academic.oup.com
Abstract Knowledge about mammalian selenoproteins is increasing. However, the
selenoproteome of birds remains considerably less understood, especially concerning its …
selenoproteome of birds remains considerably less understood, especially concerning its …
Filter-based protein digestion (FPD): a detergent-free and scaffold-based strategy for TMT workflows
High-throughput proteome profiling requires thorough optimization to achieve
comprehensive analysis. We developed a filter aided sample preparation (FASP)-like …
comprehensive analysis. We developed a filter aided sample preparation (FASP)-like …
AGGRESCAN3D: toward the prediction of the aggregation propensities of protein structures
Protein aggregation is responsible for the onset and spread of many human diseases,
ranging from neurodegenerative disorders to cancer and diabetes. Moreover, it is one of the …
ranging from neurodegenerative disorders to cancer and diabetes. Moreover, it is one of the …
A study on the structural features of SELK, an over-expressed protein in hepatocellular carcinoma, by molecular dynamics simulations in a lipid–water system
Human SELK is a small trans-membrane selenoprotein characterized by a single trans-
membrane helix, while the N-terminal region protrudes into the lumen and the long C …
membrane helix, while the N-terminal region protrudes into the lumen and the long C …
Selenium and cardiovascular disease: Epidemiological evidence of a possible U-shaped relationship
X Zhang, X Li, W Zhang, Y Song - Selenium, 2018 - Springer
Selenium is an essential mineral that plays a crucial role in the regulation of cardiovascular
system. The relation between selenium and cardiovascular disease (CVD) has been studied …
system. The relation between selenium and cardiovascular disease (CVD) has been studied …
In silico studying of the whole protein structure and dynamics of Dickkopf family members showed that N-terminal domain of Dickkopf 2 in contrary to other Dickkopfs …
Abstract Wnt (Wingless Int) signaling pathway has been known to be dysregulated in several
human cancers, especially colorectal cancer (CRC). The Dickkopf (DKK) family which …
human cancers, especially colorectal cancer (CRC). The Dickkopf (DKK) family which …
Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain?
Abstract Ephrin A2 receptor (EphA2) plays a key role in cancer, it is up-regulated in several
types of tumors and the process of ligand-induced receptor endocytosis, followed by …
types of tumors and the process of ligand-induced receptor endocytosis, followed by …