The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA–protein
complex and a precursor of the U4/U6. U5 tri-snRNP, the major building block of the …

The Protein Phosphatase type 1 catalytic subunit (PP1c)(PF3D7_1414400) operates in
combination with various regulatory proteins to specifically direct and control its …

The co-chaperone DnaJ plays an important role in protein folding and regulation of various
physiological activities, and participates in several pathological processes. DnaJ has been …

The question whether interference with the ubiquitous splicing machinery can lead to cell-
type specific perturbation of cellular function is addressed here by T cell specific ablation of …

The essential and distinct functions of Protein Phosphatase type 1 (PP1) catalytic subunit in
eukaryotes are exclusively achieved through its interaction with a myriad of regulatory …

MiRNAs post-transcriptionally regulate gene expression by recruiting the miRNA-induced
silencing complex (miRISC) to target mRNAs. However, the mechanisms by which miRISC …

Signalling to the podocyte via the structurally related insulin receptor (IR) or insulin-like
growth factor 1 receptor (IGF1) is important for podocyte function. This study sought to …

This study's goal is to determine similarities and differences in the molecular pathways or
potential functions of the various targeted regions or genes of the Vegf family—VegfA …

The prevalence of renal diseases is rising and reaching 5–15% of the adult population.
Renal damage is associated with disturbances of body homeostasis and the loss of …

Donor organ quality affects long term outcome after renal transplantation. A variety of
prognostic molecular markers is available, yet their validity often remains undetermined. A …