Estrogens as neuroprotectants: estrogenic actions in the context of cognitive aging and brain injury

EB Engler-Chiurazzi, CM Brown, JM Povroznik… - Progress in …, 2017 - Elsevier
There is ample empirical evidence to support the notion that the biological impacts of
estrogen extend beyond the gonads to other bodily systems, including the brain and …

[HTML][HTML] Traumatic brain injury in women across lifespan

MO Blaya, AP Raval, HM Bramlett - Neurobiology of disease, 2022 - Elsevier
Traumatic brain injury (TBI) is a leading cause of death and disability and a global public
health challenge. Every year more than 50 million people suffer a TBI, and it is estimated …

[HTML][HTML] Macrophagic and microglial responses after focal traumatic brain injury in the female rat

LC Turtzo, J Lescher, L Janes, DD Dean… - Journal of …, 2014 - Springer
Background After central nervous system injury, inflammatory macrophages (M1)
predominate over anti-inflammatory macrophages (M2). The temporal profile of M1/M2 …

Multipotential and systemic effects of traumatic brain injury

N Sabet, Z Soltani, M Khaksari - Journal of neuroimmunology, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of disability and mortality of people
at all ages. Biochemical, cellular and physiological events that occur during primary injury …

The role of inhaled estradiol and myrtenol, alone and in combination, in modulating behavioral and functional outcomes following traumatic experimental brain injury …

MA Rajizadeh, M Khaksari, MA Bejeshk… - Neurocritical Care, 2023 - Springer
Background Traumatic brain injury (TBI) is an important and growing cause of disability
worldwide, and its cognitive consequences may be particularly significant. This study …

[HTML][HTML] Protective effects of calorie restriction and 17-β estradiol on cardiac hypertrophy in ovariectomized obese rats

Z Hajializadeh, M Khaksari, S Dabiri… - Plos one, 2023 - journals.plos.org
Obesity and menopause lead to cardiovascular diseases. Calorie restriction (CR) can
modulate estrogen deficiency and obesity-related cardiovascular diseases. The protective …

Effects of female sex steroids administration on pathophysiologic mechanisms in traumatic brain injury

M Khaksari, Z Soltani, N Shahrokhi - Translational stroke research, 2018 - Springer
Secondary brain damage following initial brain damage in traumatic brain injury (TBI) is a
major cause of adverse outcomes. There are many gaps in TBI research and a lack of …

Possible involvement of female sex steroid hormones in intracellular signal transduction mediated by cytokines following traumatic brain injury

F Farahani, M Khaksari, S Amiresmaili, M Iranpour… - Brain research …, 2022 - Elsevier
Introduction The aim of this study was to determine the anti-inflammatory effect of female sex
hormones on the level of intracellular molecules of cytokine signaling pathway after diffuse …

[HTML][HTML] Cardioprotective and anti-inflammatory effects of G-protein coupled receptor 30 (GPR30) on postmenopausal type 2 diabetic rats

H Azizian, M Khaksari, M Esmailidehaj… - Biomedicine & …, 2018 - Elsevier
Diabetic cardiomyopathy is the most common chronic disease in postmenopausal women,
but the mechanism (s) is unclear. G-protein coupled receptor 30 (GPR30) is one of the …

[HTML][HTML] Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis

M Ziaka, A Exadaktylos - Critical Care, 2024 - Springer
It has been convincingly demonstrated in recent years that isolated acute brain injury (ABI)
may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential …