RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …

Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding
clamp for replicative DNA polymerases and as an essential component of the eukaryotic …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Base excision repair (BER) proteins act upon a significantly broad spectrum of DNA lesions
that result from endogenous and exogenous sources. Multiple sub-pathways of BER (short …

First discovered as a structure-specific endonuclease that evolved to cut at the base of
single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component …

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of
the five known family members in humans give rise to debilitating disorders that are …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

▪ Abstract One strand of cellular DNA is generated as RNA-initiated discontinuous segments
called Okazaki fragments that later are joined. The RNA terminated region is displaced into …

Base excision repair (BER) is the major pathway responsible for averting the mutagenic and
cytotoxic effects of spontaneous hydrolytic, oxidative, and non-enzymatic alkylation DNA …