Neutrophils as potential therapeutic targets in hepatocellular carcinoma
The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …
The role of macrophages in cancer development and therapy
Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …
development of tumors, modulation of neoangiogenesis, immune suppression, and …
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer
Radiotherapy (RT) of colorectal cancer (CRC) can prime adaptive immunity against tumor-
associated antigen (TAA)–expressing CRC cells systemically. However, abscopal tumor …
associated antigen (TAA)–expressing CRC cells systemically. However, abscopal tumor …
Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy
Solid tumours display a limited response to immunotherapies. By contrast, haematological
malignancies exhibit significantly higher response rates to immunotherapies as compared …
malignancies exhibit significantly higher response rates to immunotherapies as compared …
CXCR4/CXCL12 activities in the tumor microenvironment and implications for tumor immunotherapy
R Mezzapelle, M Leo, F Caprioglio, LS Colley… - Cancers, 2022 - mdpi.com
Simple Summary Chemokines are small soluble proteins that control and regulate cell
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …
trafficking within and between tissues by binding to their receptors. Among them, CXCL12 …
CD47 as a promising therapeutic target in oncology
H Zhao, S Song, J Ma, Z Yan, H Xie, Y Feng… - Frontiers in …, 2022 - frontiersin.org
CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-
recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular …
recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular …
Harnessing and enhancing macrophage phagocytosis for cancer therapy
Cancer immunotherapy has revolutionized the paradigm for the clinical management of
cancer. While FDA-approved cancer immunotherapies thus far mainly exploit the adaptive …
cancer. While FDA-approved cancer immunotherapies thus far mainly exploit the adaptive …
Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
Checkpoint inhibition immunotherapy has revolutionized cancer treatment, but many
patients show resistance. Here we perform integrative transcriptomic and proteomic …
patients show resistance. Here we perform integrative transcriptomic and proteomic …
Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses
In solid tumours, the abundance of macrophages is typically associated with a poor
prognosis. However, macrophage clusters in tumour-cell nests have been associated with …
prognosis. However, macrophage clusters in tumour-cell nests have been associated with …
[HTML][HTML] Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer
Background Limited therapeutic options are available for triple-negative breast cancer
(TNBC), emphasizing an urgent need for more effective treatment approaches. The …
(TNBC), emphasizing an urgent need for more effective treatment approaches. The …