Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Serving as the basis of cell life, interactions between nucleic acids and proteins play
essential roles in fundamental cellular processes. Aptamers are unique single-stranded …

Biomolecular condensation via liquid-liquid phase separation of proteins and nucleic acids
is associated with a range of critical cellular functions and neurodegenerative diseases …

Biomolecular condensation via liquid–liquid phase separation of intrinsically disordered
proteins/regions (IDPs/IDRs) along with other biomolecules is proposed to control critical …

Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …

The leap of retroviruses and coronaviruses from animal hosts to humans has led to two
ongoing pandemics and tens of millions of deaths worldwide. Retrovirus and coronavirus …

Aberrant protein folding underpins many neurodegenerative diseases as well as certain
myopathies and cancers. Protein misfolding can be driven by the presence of distinctive …

Liquid–liquid phase separation (LLPS) appears to be a newly appreciated aspect of the
cellular organization of biomolecules that leads to the formation of membraneless …

Conformational conversion of the α-helix-rich cellular prion protein into the misfolded, β-rich,
aggregated, scrapie form underlies the molecular basis of prion diseases that represent a …

Liquid–liquid phase separation (LLPS) and phase transitions (PT) of proteins, which include
the formation of gel-and solid-like species, have been characterized as physical processes …