Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …

The cortex is a thin, crosslinked actin network lying immediately beneath the plasma
membrane of animal cells. Myosin motors exert contractile forces in the meshwork. Because …

A long-term aim of the life sciences is to understand how organismal shape is encoded by
the genome. An important challenge is to identify mechanistic links between the genes that …

Apical constriction is a cell shape change that promotes tissue remodeling in a variety of
homeostatic and developmental contexts, including gastrulation in many organisms and …

Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By
regulating contact formation and stability, cadherins play a crucial role in tissue …

From microbial biofilm communities to multicellular organisms, 3D macroscopic structures
develop through poorly understood interplay between cellular processes and mechanical …

Epithelium folding is a basic morphogenetic event that is essential in transforming simple
two-dimensional epithelial sheets into three-dimensional structures in both vertebrates and …

Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …

The mechanical properties of the tumor microenvironment have been increasingly
recognized as potent modulators of cell behavior and function. In particular, tissue rigidity is …