Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Photoactivatable protherapeutic nanomedicine for cancer

Y Zhang, C Xu, X Yang, K Pu - Advanced Materials, 2020 - Wiley Online Library
Therapeutic systems with site‐specific pharmaceutical activation hold great promise to
enhance therapeutic efficacy while reducing systemic toxicity in cancer therapy. With …

Cyclic ruthenium-peptide conjugates as integrin-targeting phototherapeutic prodrugs for the treatment of brain tumors

L Zhang, P Wang, XQ Zhou, L Bretin… - Journal of the …, 2023 - ACS Publications
To investigate the potential of tumor-targeting photoactivated chemotherapy, a chiral
ruthenium-based anticancer warhead, Λ/Δ-[Ru (Ph2phen) 2 (OH2) 2] 2+, was conjugated to …

Combination of light and Ru (II) polypyridyl complexes: Recent advances in the development of new anticancer drugs

L Conti, E Macedi, C Giorgi, B Valtancoli… - Coordination Chemistry …, 2022 - Elsevier
The increasing impact of cancer on worldwide mortality makes the research of novel
chemotherapeutic agents a current and challenging issue. In the recent years, transition …

A Near‐Infrared Light‐Activated Photocage Based on a Ruthenium Complex for Cancer Phototherapy

G He, M He, R Wang, X Li, H Hu… - Angewandte Chemie …, 2023 - Wiley Online Library
Conventional photocages only respond to short wavelength light, which is a significant
obstacle to developing efficient phototherapy in vivo. The development of photocages …

Targeting drug delivery with light: A highly focused approach

TL Rapp, CA DeForest - Advanced drug delivery reviews, 2021 - Elsevier
Light is a uniquely powerful tool for controlling molecular events in biology. No other
external input (eg, heat, ultrasound, magnetic field) can be so tightly focused or so highly …

[HTML][HTML] Tricolor visible wavelength-selective photodegradable hydrogel biomaterials

TL Rapp, CA DeForest - Nature Communications, 2023 - nature.com
Photodynamic hydrogel biomaterials have demonstrated great potential for user-triggered
therapeutic release, patterned organoid development, and four-dimensional control over …

Heavy atom‐free, mitochondria‐targeted, and activatable photosensitizers for photodynamic therapy with real‐time in‐situ therapeutic monitoring

J Miao, Y Huo, G Yao, Y Feng, J Weng… - Angewandte Chemie …, 2022 - Wiley Online Library
Based on spin‐orbit charge transfer intersystem crossing mechanism, two heavy‐atom‐free
photosensitizers (PSs) BDP1/BDP2 with absorption maxima at 506 nm/660 nm were …