Facilitating the molecular diagnosis of rare genetic disorders through facial phenotypic scores

TC Hsieh, H Lesmann, PM Krawitz - Current Protocols, 2023 - Wiley Online Library
With recent advances in computer vision, many applications based on artificial intelligence
have been developed to facilitate the diagnosis of rare genetic disorders through the …

Landscape of Constitutional SOX4 Variation in Human Disorders

M Grippa, C Graziano - Genes, 2024 - mdpi.com
SOX proteins are transcription factors which play a role in regulating the development of
progenitor cells and tissue differentiation. Twenty members are known, clustered in eight …

Next‐generation phenotyping in Nigerian children with Cornelia de Lange Syndrome

A Arlt, A Knaus, TC Hsieh… - American Journal of …, 2024 - Wiley Online Library
Next‐generation phenotyping (NGP) can be used to compute the similarity of dysmorphic
patients to known syndromic diseases. So far, the technology has been evaluated in variant …

GestaltMatcher Database-A global reference for facial phenotypic variability in rare human diseases

H Lesmann, A Hustinx, S Moosa… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
The most important factor that complicates the work of dysmorphologists is the significant
phenotypic variability of the human face. Next-Generation Phenotyping (NGP) tools that …