Nicotine is the predominant addictive compound of tobacco and causes the acquisition of
dependence through its interactions with nicotinic acetylcholine receptors and various …

The complex nature of the transcriptional networks underlying addictive behaviors suggests
intricate cooperation between diverse gene regulation mechanisms that go beyond …

Homeostatic synaptic plasticity is a non-Hebbian synaptic mechanism that adjusts synaptic
strength to maintain network stability while achieving optimal information processing. Among …

Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of
hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels …

Fatty acid binding proteins (FABPs) govern intracellular lipid transport to cytosolic organelles
and nuclear receptors. More recently, FABP5 has emerged as a key regulator of synaptic …

Frustrative nonreward (FN) is a construct in the Negative Valence Systems domain of the
Research Domain Criteria (RDoC) from the National Institute of Mental Health. An …

Cocaine use disorder (CUD) is a prevalent neuropsychiatric disorder with few existing
treatments. Thus, there is an unmet need for the identification of new pharmacological …

Rationale Incubation of cocaine craving refers to the progressive intensification of cue-
induced craving during abstinence from cocaine self-administration. We showed previously …

Fatty acid binding proteins (FABPs) are intracellular chaperones that deliver bioactive lipids
to cytosolic enzymes and nuclear receptors, thereby regulating diverse biological functions …

Cannabis is one of the most commonly used psychoactive substances, which could induce
moderate-severe cannabis use disorders (CUD). Here, a tissue-specific transcriptome-wide …