Dietary metabolism, the gut microbiome, and heart failure

WHW Tang, DY Li, SL Hazen - Nature Reviews Cardiology, 2019 - nature.com
Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

Butyrate to combat obesity and obesity‐associated metabolic disorders: Current status and future implications for therapeutic use

T van Deuren, EE Blaak, EE Canfora - Obesity Reviews, 2022 - Wiley Online Library
Evidence is increasing that disturbances in the gut microbiome may play a significant role in
the etiology of obesity and type 2 diabetes. The short chain fatty acid butyrate, a major end …

[HTML][HTML] The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

G Den Besten, K Van Eunen, AK Groen, K Venema… - Journal of lipid …, 2013 - ASBMB
Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the
anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on …

Short chain fatty acids in human gut and metabolic health

EE Blaak, EE Canfora, S Theis, G Frost… - Beneficial …, 2020 - wageningenacademic.com
Evidence is accumulating that short chain fatty acids (SCFA) play an important role in the
maintenance of gut and metabolic health. The SCFA acetate, propionate and butyrate are …

[HTML][HTML] Short-chain fatty acid transporters: role in colonic homeostasis

S Sivaprakasam, YD Bhutia, S Yang… - Comprehensive …, 2017 - ncbi.nlm.nih.gov
Short-chain fatty acids (SCFA; acetate, propionate, and butyrate) are generated in colon by
bacterial fermentation of dietary fiber. Though diffusion in protonated form is a significant …

Short‐chain fatty acids: ready for prime time?

CC Roy, CL Kien, L Bouthillier… - Nutrition in clinical …, 2006 - Wiley Online Library
The concept of colonic health has become a major target for the development of functional
foods such as probiotics, prebiotics, and synbiotics. These bioactive agents have a profound …

Role of colonic short-chain fatty acid transport in diarrhea

HJ Binder - Annual review of physiology, 2010 - annualreviews.org
Short-chain fatty acids (SCFA) are the major anion in stool and are synthesized from
nonabsorbed carbohydrate by the colonic microbiota. Nonabsorbed carbohydrate are not …

A look at the smelly side of physiology: transport of short chain fatty acids

F Stumpff - Pflügers Archiv-European Journal of Physiology, 2018 - Springer
Fermentative organs such as the caecum, the colon, and the rumen have evolved to
produce and absorb energy rich short chain fatty acids (SCFA) from otherwise indigestible …

[HTML][HTML] Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease

R Freire, L Ingano, G Serena, M Cetinbas, A Anselmo… - Scientific reports, 2019 - nature.com
Celiac disease (CD) is an immune-mediated disorder triggered by gluten exposure. The
contribution of the adaptive immune response to CD pathogenesis has been extensively …

Intestinal secretory mechanisms and diarrhea

SJ Keely, KE Barrett - American Journal of Physiology …, 2022 - journals.physiology.org
One of the primary functions of the intestinal epithelium is to transport fluid and electrolytes
to and from the luminal contents. Under normal circumstances, absorptive and secretory …