Error s in protein synthesis disrupt cellular fitness, cause disease phenotypes and shape
gene and genome evolution. Experimental and theoretical results on this topic have …

In unpredictably varying environments, strategies that have a reduced variance in fitness
can invade a population consisting of individuals that on average do better. Such strategies …

Prions are proteins that convert between structurally and functionally distinct states, one or
more of which is transmissible. In yeast, this ability allows them to act as non-Mendelian …

Genetically identical cells grown in the same culture display striking cell-to-cell
heterogeneity in gene expression and other traits. A crucial challenge is to understand how …

Biological systems are robust to perturbation by mutations and environmental fluctuations.
New data are shedding light on the biochemical and network-level mechanisms responsible …

How and when the microbiome modulates host adaptation remains an evolutionary puzzle,
despite evidence that the extended genetic repertoire of the microbiome can shape host …

Why isn't random variation always deleterious? Are there factors that sometimes make
adaptation easier? Biological systems are extraordinarily robust to perturbation by …

Regulatory and developmental systems produce phenotypes that are robust to
environmental and genetic variation. A gene product that normally contributes to this …

Phenotypic diversification plays a central role in evolution and provides species with a
capacity to survive environmental adversity. The profound impact of random molecular …

What factors shape the evolution of invasive populations? Recent theoretical and empirical
studies suggest that an evolutionary history of disturbance might be an important factor. This …