Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Context Hypoglycemia in people with diabetes is common, especially in those taking
medications such as insulin and sulfonylureas (SU) that place them at higher risk …

Variability in the effect of subcutaneously administered insulin represents a major challenge
in insulin therapy where precise dosing is required in order to achieve targeted glucose …

Insulin therapy or intensification of insulin therapy commonly results in weight gain in both
type 1 and type 2 diabetes. This weight gain can be excessive, adversely affecting …

Background Adding insulin to oral therapy in type 2 diabetes mellitus is customary when
glycemic control is suboptimal, though evidence supporting specific insulin regimens is …

OBJECTIVE—To assess efficacy and tolerability of insulin detemir or NPH insulin added to
oral therapy for type 2 diabetes in a treat-to-target titration protocol. RESEARCH DESIGN …

Aims/hypothesis This 52-week multinational, randomised, open-label, parallel-group, non-
inferiority trial compared clinical outcomes following supplementation of oral glucose …

Purpose To define and understand patient psychological insulin resistance (PIR) and its
impact on diabetes management. Methods Systematic literature review of peer-refereed …

Background: Although insulin analogues are commonly prescribed for the management of
diabetes mellitus, there is uncertainty regarding their optimal use. We conducted meta …

BACKGROUND:: Many patients with poorly controlled type 2 diabetes mellitus (DM) receive,
as initial insulin treatment, the addition of a basal formulation to an existing regimen of oral …