Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs

S Pinheiro, EMC Pinheiro, EMF Muri… - Medicinal Chemistry …, 2020 - Springer
Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …

Metallodrugs for the treatment of trypanosomatid diseases: Recent advances and new insights

M Navarro, R Justo, GYS Delgado… - Current Pharmaceutical …, 2021 - ingentaconnect.com
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

First-Row Transition 7-Oxo-5-phenyl-1, 2, 4-triazolo [1, 5-a] pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies

Á Martín-Montes, S Jimenez-Falcao, S Gómez-Ruiz… - Pharmaceuticals, 2023 - mdpi.com
Leishmaniasis and Chagas disease are still considered neglected illnesses due to the lack
of investment in research, despite the fact that almost one million new cases are reported …

Biological activity of triazolopyrimidine copper (II) complexes modulated by an auxiliary NN-chelating heterocycle ligands

LL Ruta, IC Farcasanu, M Bacalum, M Răileanu… - Molecules, 2021 - mdpi.com
Novel complexes of type [Cu (NN)(dmtp) 2 (OH2)](ClO4) 2· dmtp ((1) NN: 2, 2′-
bipyridine;(2) L: 1, 10-phenantroline and dmtp: 5, 7-dimethyl-1, 2, 4-triazolo [1, 5-a] …

New organometallic ruthenium (II) complexes with purine analogs–a wide perspective on their biological application

M Fandzloch, T Jędrzejewski, L Dobrzańska… - Dalton …, 2021 - pubs.rsc.org
Three half-sandwich organometallic ruthenium (II) complexes containing purine analogs
such as triazolopyrimidines of general formula [(η6-p-cym) Ru (L) Cl2], where p-cym …

Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1, 2, 4-triazolo [1, 5-a] pyrimidine …

GM Esteban-Parra, E San Sebastián, J Cepeda… - Journal of Inorganic …, 2020 - Elsevier
We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1, 2, 4-
triazolo [1, 5-a] pyrimidine (7-amtp), and a new family of coordination compounds based on …

Multifunctional 1, 10-phenanthroline derivative and its metal complexes as an anti-Alzheimer's agent: structure-based drug design, synthesis, characterization and …

EHE Gladis, K Nagashri, A Suman… - Journal of Coordination …, 2020 - Taylor & Francis
N-Heterocycles are structural constituents of pharmaceuticals based on FDA approved
therapeutic agents with more than 60% of drugs containing N-heterocycles as building …

Growth, single crystal investigation, hirshfeld surface analysis, DFT studies, molecular docking, physico-chemical characterization and, in vitro, antioxidant activity of a …

Y Oueslati, Y El Bakri, A Valkonen, CJG García… - Journal of Solid State …, 2021 - Elsevier
Interaction of the diphosphoric acid (H 4 P 2 O 7) and organic ligand (3.4-dimethylaniline)
with transition metal ions, cobalt (II) chloride leads to the formation of novel stable Co (II) …

In vitro evaluation of leishmanicidal properties of a new family of monodimensional coordination polymers based on diclofenac ligand

A García-García, JM Mendez-Arriaga… - Polyhedron, 2020 - Elsevier
Some series of isostructural chains with general formula [M (diclof) 2 (H 2 O) 2]·(EtOH) 2
have been obtained from reaction between diclofenac ligand (diclof) and first row transition …

[HTML][HTML] Recent Advances in Metal Complexes Based on Biomimetic and Biocompatible Organic Ligands against Leishmaniasis Infections: State of the Art and …

S Jimenez-Falcao, JM Mendez-Arriaga - Inorganics, 2024 - mdpi.com
Leishmaniasis is a complex disease present in a variety of manifestations listed by the World
Health Organization (WHO) as one of the neglected diseases with a worse prognosis if not …