Photodynamic therapy (PDT) utilizes light-activated photosensitizers (PSs) to generate toxic
species for therapeutics. It has become an emerging solution for cancer treatment because …

Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Abstract Cancer-associated fibroblasts (CAFs)-mediated metabolic support plays a vital role
in tumorigenesis. The metabolic network between cancer cells and CAFs may serve as …

Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates
cell proliferation, invasion and immunological reaction during cancer progression. Here, we …

The blood–brain barrier (BBB) is a highly regulated and efficient barrier that controls the
mass transfer between blood and brain, severely limits brain penetration of systemically …

Human glucose transporters (GLUTs) are responsible for cellular uptake of hexoses.
Elevated expression of GLUTs, particularly GLUT1 and GLUT3, is required to fuel the …

Lactate represents the main product of pyruvate reduction catalyzed by the lactic
dehydrogenase family of enzymes. Cancer cells utilize great quantities of glucose, shifting …

Breast cancer (BC) is the most common malignancy in women worldwide, and the standard
treatment is chemotherapy or radiotherapy after surgery. In order to reduce the side effects of …