Although 5-fluorouracil (5-FU)-based chemotherapy is the major treatment for colorectal
cancer, it has disadvantages such as systemic toxicity, lack of effectiveness and selectivity …

The rapid increase in antibiotic-resistant bacteria has emphasized the urgent need to
identify new treatments for bacterial infections. One attractive approach, reducing the need …

Due to the dangerous side effects of chemotherapy, advanced methods for curing cancer,
such as drug delivery, have attracted much attention because of their high efficacies. Using …

Heterocyclic derivatives as a major group of organic compounds are enormously used for a
wide range of pharmaceutical and industrial applications. They are known for their biological …

Background and Objectives: It is generally accepted that inflammatory cells found in the
tumor microenvironment are involved in the neoplastic process, promoting cell proliferation …

Nucleophilic aromatic substitution (SNAr) is routinely used to install 19F–and 18F–in
aromatic molecules, but is typically limited to electron-deficient arenes due to kinetic barriers …

Cancer has remained one of the leading causes of death worldwide, with a lack of effective
treatment. The intrinsic shortcomings of conventional therapeutics regarding tumor …

Abstract In the 1990s, 5-fluorouracil (5-FU) was introduced as a treatment for keloids;
however, there is still no consensus on its use. In order to guide clinical practice, a …

Thymidylate synthase (TS) has emerged as a hot spot in cancer treatment, as it is directly
involved in DNA synthesis. In the present article, nine hybrids containing 1, 2, 3-triazole and …

Cancer is incurable because progressive phenotypic and genotypic changes in cancer cells
lead to resistance and recurrence. This indicates the need for the development of new drugs …