Somatic rearrangements resulting in genomic structural variation drive malignant
phenotypes by altering the expression or function of cancer genes. Pan-cancer studies have …

Lysosomal membrane permeabilization and subsequent leakage of lysosomal hydrolases
into the cytosol are considered as the major hallmarks of evolutionarily conserved lysosome …

Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail
of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen …

Subcellular location and activation of Tank Binding Kinase 1 (TBK1) govern precise
progression through mitosis. Either loss of activated TBK1 or its sequestration from the …

Accurate chromosome segregation requires assembly of the multiprotein kinetochore
complex at centromeres. In most eukaryotes, kinetochore assembly is primed by the histone …

During mitosis, cells round up and utilize the interphase adhesion sites within the fibrous
extracellular matrix (ECM) as guidance cues to orient the mitotic spindles. Here, using …

Precise spatiotemporal control of microtubule nucleation and organization is critical for
faithful segregation of cytoplasmic and genetic material during cell division and signaling via …

Targeting the B-cell receptor and phosphatidylinositol 3-kinase/mTOR signaling pathways
has shown meaningful, but incomplete, antitumor activity in lymphoma. Glycogen synthase …

Cancer cells undergo uncontrolled proliferation resulting from aberrant activity of various cell-
cycle proteins. Therefore, despite recent advances in intensive chemotherapy, it is difficult to …

Micronuclei, small DNA-containing structures separate from the main nucleus, were used for
decades as an indicator of genotoxic damage. Micronuclei containing whole chromosomes …