Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
histone sliding, ejection or the incorporation of histone variants, suggesting that different …
Understanding nucleosome dynamics and their links to gene expression and DNA replication
WKM Lai, BF Pugh - Nature reviews Molecular cell biology, 2017 - nature.com
Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …
interactions at unprecedented spatial and temporal resolution. This has led to a profound …
Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
The interaction landscape between transcription factors and the nucleosome
Nucleosomes cover most of the genome and are thought to be displaced by transcription
factors in regions that direct gene expression. However, the modes of interaction between …
factors in regions that direct gene expression. However, the modes of interaction between …
[HTML][HTML] Transcription factor dynamics: one molecule at a time
K Wagh, DA Stavreva, A Upadhyaya… - Annual Review of Cell …, 2023 - annualreviews.org
Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …
biochemical and biophysical cues within their environment. This information is transmitted to …
[HTML][HTML] Genomic nucleosome organization reconstituted with pure proteins
N Krietenstein, M Wal, S Watanabe, B Park… - Cell, 2016 - cell.com
Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …
their individual contributions are obfuscated by the complex in vivo milieu of factor …
[HTML][HTML] Steroid receptors reprogram FoxA1 occupancy through dynamic chromatin transitions
EE Swinstead, TB Miranda, V Paakinaho, S Baek… - Cell, 2016 - cell.com
The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1
(FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in …
(FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in …
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens
N Liscovitch-Brauer, A Montalbano, J Deng… - Nature …, 2021 - nature.com
CRISPR screens have been used to connect genetic perturbations with changes in gene
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …
expression and phenotypes. Here we describe a CRISPR-based, single-cell combinatorial …
[HTML][HTML] RSC-associated subnucleosomes define MNase-sensitive promoters in yeast
S Brahma, S Henikoff - Molecular cell, 2019 - cell.com
The classic view of nucleosome organization at active promoters is that two well-positioned
nucleosomes flank a nucleosome-depleted region (NDR). However, this view has been …
nucleosomes flank a nucleosome-depleted region (NDR). However, this view has been …