Building and regenerating the lung cell by cell
JA Whitsett, TV Kalin, Y Xu… - Physiological …, 2019 - journals.physiology.org
The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
FOXM1: a multifunctional oncoprotein and emerging therapeutic target in ovarian cancer
Simple Summary Ovarian cancer is a lethal disease in women with a 10-year survival rate
of< 40% worldwide. A key molecular alteration in ovarian cancer is the aberrant …
of< 40% worldwide. A key molecular alteration in ovarian cancer is the aberrant …
Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling
Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …
Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling
Pulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis
and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through …
and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through …
Ultra-high dose-rate proton FLASH improves tumor control
Background and purpose Proton radiotherapy (PRT) offers potential benefits over other
radiation modalities, including photon and electron radiotherapy. Increasing the rate at …
radiation modalities, including photon and electron radiotherapy. Increasing the rate at …
FOXM1: a potential therapeutic target in human solid cancers
Introduction: FOXM1 is one of the most frequently overexpressed proteins in human solid
cancers. Here, we discuss novel direct targets of FOXM1 as well as new pathways involving …
cancers. Here, we discuss novel direct targets of FOXM1 as well as new pathways involving …
In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation
Rationale: The regeneration and replacement of lung cells or tissues from induced
pluripotent stem cell–or embryonic stem cell–derived cells represent future therapies for life …
pluripotent stem cell–or embryonic stem cell–derived cells represent future therapies for life …
FOXF1 inhibits pulmonary fibrosis by preventing CDH2-CDH11 cadherin switch in myofibroblasts
M Black, D Milewski, T Le, X Ren, Y Xu… - Cell reports, 2018 - cell.com
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant accumulation of collagen-
secreting myofibroblasts. Development of effective therapies is limited due to incomplete …
secreting myofibroblasts. Development of effective therapies is limited due to incomplete …
Nanoparticle delivery of STAT3 alleviates pulmonary hypertension in a mouse model of alveolar capillary dysplasia
Background: Pulmonary hypertension (PH) is a common complication in patients with
alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe …
alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe …
Generation of pulmonary endothelial progenitor cells for cell-based therapy using interspecies mouse–rat chimeras
Rationale: Although pulmonary endothelial progenitor cells (EPCs) hold promise for cell-
based therapies for neonatal pulmonary disorders, whether EPCs can be derived from …
based therapies for neonatal pulmonary disorders, whether EPCs can be derived from …