Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian
cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G1 to S phase transition …

Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the u
nfolded p rotein r esponse (UPR)-signaling pathway. The UPR coordinates the induction of …

Bop1 is a novel nucleolar protein involved in rRNA processing and ribosome assembly. We
have previously shown that expression of Bop1Δ, an amino-terminally truncated Bop1 that …

Alterations in normal protein biogenesis and the resulting accumulation of improperly folded
proteins in the endoplasmic reticulum (ER) trigger a stress response that up-regulates the …

The thiazolidinedione (TZD) class of peroxisome proliferator-activated receptor (PPAR) γ
ligands, known for their ability to induce adipocyte differentiation and increase insulin …

Phosphorylation of serine 51 residue on the α-subunit of eukaryotic initiation factor 2 (eIF2α)
inhibits the guanine nucleotide exchange (GNE) activity of eIF2B, presumably, by forming a …

Protein synthesis in eukaryotes is a complex process which can be regulated at many points
in the pathway. In recent years it has become clear that both the overall rate of translation …

Translation initiation is regulated in response to nutrient availability and mitogenic
stimulation and is coupled with cell cycle progression and cell growth. Several alterations in …

There is now a growing body of evidence which suggests links between the regulation of
protein synthesis and the disruption of cell behaviour that typifies cancer. This directed issue …