A formal demonstration that mammalian pluripotent stem cells possess preimplantation
embryonic cell-like (naive) pluripotency is the generation of chimeric animals through early …

In mammals, the sex of the embryo is determined during development by its commitment
either to the male or female genetic program regulating testicular or ovarian organogenesis …

Previous reports and the current study have found that germ cell precursor cells appear in
embryoid bodies (EBs) formed from mouse embryonic stem cells as identified by positive …

Acrosome reaction is often referred to as acrosomal exocytosis, but it differs significantly
from normal exocytosis. While the vesicle membrane initially holding excreting molecules …

Meiosis is a cell division process with complex chromosome events where various
molecules must work in tandem. To find meiosis-related genes, we screened evolutionarily …

Spermatozoa have a streamlined shape to swim through the oviduct to fertilize oocytes. To
become svelte spermatozoa, spermatid cytoplasm must be eliminated in several steps …

Wild-derived mouse strains have been extensively used in biomedical research because of
the high level of inter-strain polymorphisms and phenotypic variations. However, they often …

Ten to 15% of couples are infertile, with the most common causes being linked to the
production of few or no oocytes or sperm. Yet, our understanding of human germ cell …

In mammals, male sex determination is governed by SRY-dependent activation of Sox9,
whereas female development involves R-spondin1 (RSPO1), an activator of the WNT/beta …

In mammals, the Y chromosome strictly influences the maintenance of male germ cells.
Almost all mammalian species require genetic contributors to generate testes. An …