The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

Many fields in chemical biology and synthetic biology require effective bioconjugation
methods to achieve their desired functions and activities. Among such biomolecule …

Cysteine-maleimide chemistry is widely used for peptide and protein modification. However,
the formed succinimide linkage is readily hydrolyzed and is susceptible to an exchange …

Immunosuppressants are clinically approved drugs to treat the potential rejection of
transplanted organs and require frequent monitoring due to their narrow therapeutic …

Over the last two decades, the development of chemical biology and the need for more
defined protein conjugates have fostered active research on new bioconjugation …

Monoclonal antibodies (mAbs) and their derivatives are currently the fastest growing class of
therapeutics. Even if naked antibodies have proven their value as successful …

Aryl transfer reactions from arenediazonium salts have started to make their impact in
chemical biology with initial forays in the arena of arylative modifications and bio …

This review highlights some of the recent advances made in our understanding of the
diversity of tyrosine biochemistry and shows how this has inspired novel applications in …

Antibodies are desirable as therapeutics due to their ability to recognize targets with both
specificity and high affinity. Furthermore, the ability of antibodies to stimulate Fc-mediated …

Targeted immunotherapies capitalize on the exceptional binding capabilities of antibodies to
stimulate a host response that effectuates long‐lived tumor destruction. One example is the …