[HTML][HTML] The Mediator complex as a master regulator of transcription by RNA polymerase II
WF Richter, S Nayak, J Iwasa, DJ Taatjes - Nature Reviews Molecular …, 2022 - nature.com
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
JA Castro-Mondragon, R Riudavets-Puig… - Nucleic acids …, 2022 - academic.oup.com
Abstract JASPAR (http://jaspar. genereg. net/) is an open-access database containing
manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six …
manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six …
[HTML][HTML] In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization
E Oberbeckmann, K Quililan, P Cramer… - Nature Genetics, 2024 - nature.com
Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …
driving the formation of these domains are difficult to dissect in vivo and remain poorly …
Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT
H Ehara, T Kujirai, M Shirouzu, H Kurumizaka… - Science, 2022 - science.org
During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin,
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
[HTML][HTML] Structures of transcription preinitiation complex engaged with the+ 1 nucleosome
The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position
RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the …
RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the …
[HTML][HTML] Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization
Centromeres are specialized chromosome loci that seed the kinetochore, a large protein
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …
complex that effects chromosome segregation. A 16-subunit complex, the constitutive …
Establishment and function of chromatin organization at replication origins
E Chacin, KU Reusswig, J Furtmeier, P Bansal, LA Karl… - Nature, 2023 - nature.com
The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome
replication as it loads the replicative helicase—the minichromosome maintenance (MCM) …
replication as it loads the replicative helicase—the minichromosome maintenance (MCM) …
Transcription-coupled nucleosome assembly
F Robert, C Jeronimo - Trends in Biochemical Sciences, 2023 - cell.com
Eukaryotic transcription occurs on chromatin, where RNA polymerase II encounters
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …
nucleosomes during elongation. These nucleosomes must unravel for the DNA to enter the …