Oxidative stress and 4‐hydroxy‐2‐nonenal (4‐HNE): Implications in the pathogenesis and treatment of aging‐related diseases
Y Li, T Zhao, J Li, M Xia, Y Li, X Wang… - Journal of …, 2022 - Wiley Online Library
Oxidative stress plays an important role in the development of aging‐related diseases by
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem
K Evangelou, PVS Vasileiou… - Physiological …, 2023 - journals.physiology.org
Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …
immense impact on patient quality of life and disability. Clinical evidence has revealed a …
[HTML][HTML] Polygenic basis and biomedical consequences of telomere length variation
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
senescence. Here we characterize the genetic architecture of naturally occurring variation in …
Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank
Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …
Vascular smooth muscle cells in atherosclerosis
MR Bennett, S Sinha, GK Owens - Circulation research, 2016 - Am Heart Assoc
The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that
aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced …
aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced …
[HTML][HTML] Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation
V Vaccarino, L Badimon, JD Bremner… - European heart …, 2020 - academic.oup.com
Major depression is a highly prevalent condition, affecting approximately 10% of the
population. 1 It is also a growing global problem, 2 and has been consistently associated …
population. 1 It is also a growing global problem, 2 and has been consistently associated …
The aging cardiovascular system: understanding it at the cellular and clinical levels
Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers,
and health systems. Structural and functional alterations of vessels accumulate throughout …
and health systems. Structural and functional alterations of vessels accumulate throughout …
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
PC Haycock, EE Heydon, S Kaptoge, AS Butterworth… - Bmj, 2014 - bmj.com
Objective To assess the association between leucocyte telomere length and risk of
cardiovascular disease. Design Systematic review and meta-analysis. Data sources Studies …
cardiovascular disease. Design Systematic review and meta-analysis. Data sources Studies …
[HTML][HTML] SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …