The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

A significant number of drugs and drug candidates in clinical development are halogenated
structures. For a long time, insertion of halogen atoms on hit or lead compounds was …

Provides a thorough overview of the role of fluorine in pharmaceutical science and
development Includes chapters on fluorinated analogues of natural products, fluorinated …

General anaesthetics are much more selective than is usually appreciated and may act by
binding to only a small number of targets in the central nervous system. At surgical …

Volatile anesthetics produce safe, reversible unconsciousness, amnesia and analgesia via
hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate …

General anesthetics are essential to modern medicine, and yet a detailed understanding of
their mechanisms of action is lacking. General anesthetics were once believed to be 'drugs …

Abstract Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane
segments and two pore-forming domains that are arranged in tandem and function as either …

Ethanol is a chemically simple compound that produces many well-known effects in
humans. The prevailing idea for many years was that ethanol and other alcohols exerted …

In this review first we evaluate evidence on the role of the neurobiological alterations
induced by chronic ethanol consumption in the development of ethanol tolerance …

The well-known correlation between the hydrophobicity of narcotic chemicals and the
exposure concentration needed to produce an effect indicates that a lipid phase in the …