A central reason behind the poor clinical outcome of patients with high-grade serous
carcinoma (HGSC) of the ovary is the difficulty in reliably detecting early occurrence or …

TMPRSS2 is an important membrane-anchored serine protease involved in human prostate
cancer progression and metastasis. A serine protease physiologically often comes together …

Unlike in normal epithelium, dysregulated overactivation of various proteases have been
reported in cancers. Degradation of pericancerous extracellular matrix leading to cancer cell …

Thoracic aortic dissection (TAD) is a severe and extremely dangerous cardiovascular
disease. Proliferation, migration and phenotypic switching of vascular smooth muscle cells …

Background: Research on the discovery of tumor biomarkers based on big data analysis is
actively being conducted. This study aimed to secure foundational data for identifying new …

Objective. We conducted a meticulous bioinformatics analysis leveraging expression data of
226 PANRGs obtained from previous studies, as well as clinical data from AML patients …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide.
However, the molecular mechanisms underlying NSCLC progression remains not fully …

RNA splicing shapes the gene regulatory programs that underlie various physiological and
disease processes. Here, we present the SCASL (single-cell clustering based on alternative …

Viruses possessing class I fusion proteins require proteolytic activation by host cell
proteases to mediate fusion with the host cell membrane. The mammalian SPINT2 gene …

Background OS is the most common malignant tumor of bone which was featured with
osteoid or immature bone produced by the malignant cells, and biomarkers are urgently …