Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion

A Srinivasan, P Sathiyanathan, L Yin, TM Liu, A Lam… - Cytotherapy, 2022 - Elsevier
Therapies using mesenchymal stromal cells (MSCs) to treat immune and inflammatory
conditions are now at an exciting stage of development, with many MSC-based products …

Update on novel non-operative treatment for osteoarthritis: current status and future trends

T Chen, W Weng, Y Liu, RH Aspera-Werz… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a leading cause of pain and disability which results in a reduced
quality of life. Due to the avascular nature of cartilage, damaged cartilage has a finite …

[HTML][HTML] Mechano-responsive hydrogel for direct stem cell manufacturing to therapy

Y Shou, L Liu, Q Liu, Z Le, KL Lee, H Li, X Li, DZ Koh… - Bioactive Materials, 2023 - Elsevier
Bone marrow-derived mesenchymal stem cell (MSC) is one of the most actively studied cell
types due to its regenerative potential and immunomodulatory properties. Conventional cell …

[HTML][HTML] Recent trends in stem cell-based therapies and applications of artificial intelligence in regenerative medicine

S Mukherjee, G Yadav, R Kumar - World journal of stem cells, 2021 - ncbi.nlm.nih.gov
Stem cells are undifferentiated cells that can self-renew and differentiate into diverse types
of mature and functional cells while maintaining their original identity. This profound …

[PDF][PDF] Biologics in interventional spinal procedure: The past, the present, and the vision

A Navani - Pain Physician, 2023 - painphysicianjournal.com
Background: Orthobiologics have shown promise in repair, restoration and regeneration of
damaged and degenerated spine, joint and musculoskeletal tissues. The role of MSCs is to …

Proteomic Analysis of Hypoxia‐Induced Senescence of Human Bone Marrow Mesenchymal Stem Cells

L Mai, G He, J Chen, J Zhu, S Chen… - Stem Cells …, 2021 - Wiley Online Library
Background and Aim. The senescence of human bone marrow mesenchymal stem cells
(hBMSCs) can be induced by oxidative stress, but the mechanism by which it occurs is not …

Integrating artificial intelligence to biomedical science: New applications for innovative stem cell research and drug development

M Kim, S Hong - Technologies, 2024 - mdpi.com
Artificial intelligence (AI) is rapidly advancing, aiming to mimic human cognitive abilities, and
is addressing complex medical challenges in the field of biological science. Over the past …

The global evolution and impact of systems biology and artificial intelligence in stem cell research and therapeutics development: a scoping review

T Silva-Sousa, JN Usuda, N Al-Arawe, F Frias… - Stem Cells, 2024 - academic.oup.com
Advanced bioinformatics analysis, such as systems biology (SysBio) and artificial
intelligence (AI) approaches, including machine learning (ML) and deep learning (DL), is …

[HTML][HTML] Evidence-based machine learning algorithm to predict failure following cartilage procedures in the knee

R Gilat, B Gilat, K Wagner, S Patel… - Journal of Cartilage & …, 2023 - Elsevier
Introduction Clinical decision-making is highly based on expert opinion. Machine learning is
increasingly used to develop patient-specific risk prediction analysis to improve patient …

Advancements of artificial intelligence-driven approaches in the use of stem cell therapy in diseases or disorders: clinical applications and ethical issues

V Suresh, J De Joseph, G Manasa… - The …, 2024 - the.evidencejournals.com
The convergence of artificial intelligence (AI) and stem cell therapy marks a transformative
advancement in regenerative medicine. This manuscript explores how AI-driven approaches …