Objective: To review the present status of bioartificial liver (BAL) devices and their obtained
clinical results. Background: Acute liver failure (ALF) is a disease with a high mortality …

Acute liver failure (ALF) is a disease with a mortality of 60–90% depending on the cause.
Only high-urgency liver transplantation is able to increase survival compared to standard …

Aim of the study was to evaluate treatment efficacy and safety of a scaled-up version of our
porcine hepatocytes based BAL system in pigs with complete liver ischemia (LIS). Thirty-one …

Background: Porcine endogenous retrovirus (PERV) remains a safety risk in pig‐to‐human
xenotransplantation. There is no evidence of in vivo productive infection in humans because …

Rapid advances in development of bioartificial liver assist devices (BLADs) are exciting
clinical interest in the application of BLAD technology for support of patients with acute liver …

The variety of methods for measuring bioactive mass and functionality of bioartificial livers
(BAL) is confusing and prevents accurate comparison of reported data. Here we present a …

Presently, there is growing interest on telomerase activity in all cells (somatic cells, stem
cells, cancerous cells and others) since this activity is associated with cellular changes such …

Culture media are frequently used in the evaluation of metabolical functions of hepatocytes
in hybrid liver support systems (hLSS). However, media compositions differ substantially …

The ramifications of using whole blood or plasma for perfusion of an hepatocyte containing
bioartificial liver bioreactor in which the hepatocytes are separated by a membrane or other …

Primary hepatocytes have extensively been used in biochemical, pharmacological, and
physiological research. Recently, primary porcine hepatocytes have been regarded as the …