[HTML][HTML] MicroRNAs in stress signaling and human disease
JT Mendell, EN Olson - Cell, 2012 - cell.com
Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …
Evolution of microRNA diversity and regulation in animals
E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …
[HTML][HTML] Hereditary breast and ovarian cancer susceptibility genes
H Kobayashi, S Ohno, Y Sasaki… - Oncology …, 2013 - spandidos-publications.com
Women with hereditary breast and ovarian cancer (HBOC) syndrome represent a unique
group who are diagnosed at a younger age and result in an increased lifetime risk for …
group who are diagnosed at a younger age and result in an increased lifetime risk for …
[HTML][HTML] Targets of miR-200c mediate suppression of cell motility and anoikis resistance
Introduction miR-200c and other members of the miR-200 family promote epithelial identity
by directly targeting ZEB1 and ZEB2, which repress E-cadherin and other genes involved in …
by directly targeting ZEB1 and ZEB2, which repress E-cadherin and other genes involved in …
[HTML][HTML] Machine learning and bioinformatics models to identify gene expression patterns of ovarian cancer associated with disease progression and mortality
Ovarian cancer (OC) is a common cause of cancer death among women worldwide, so there
is a pressing need to identify factors influencing OC mortality. Much OC patient clinical data …
is a pressing need to identify factors influencing OC mortality. Much OC patient clinical data …
Statistical methods for genome-wide association studies
Genome-wide association studies (GWAS) detect common genetic variants associated with
complex disorders. With their comprehensive coverage of common single nucleotide …
complex disorders. With their comprehensive coverage of common single nucleotide …
Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification
L Zhang, Y Liu, F Song, H Zheng… - Proceedings of the …, 2011 - National Acad Sciences
We have evaluated and provided evidence that the ryanodine receptor 3 gene (RYR3),
which encodes a large protein that forms a calcium channel, is important for the growth …
which encodes a large protein that forms a calcium channel, is important for the growth …
MicroRNAs as therapeutic targets in cancer
SP Nana-Sinkam, CM Croce - Translational Research, 2011 - Elsevier
Cancer remains a worldwide epidemic. An improved understanding of the underlying
molecular mechanisms and development of effective targeted therapies are still required for …
molecular mechanisms and development of effective targeted therapies are still required for …
MicroRNA 135 regulates HOXA10 expression in endometriosis
R Petracco, O Grechukhina… - The Journal of …, 2011 - academic.oup.com
Abstract Context: Homeo box A10 (HOXA10) regulates endometrial receptivity and its
expression is decreased in women with endometriosis. Although sex steroids regulate …
expression is decreased in women with endometriosis. Although sex steroids regulate …
[HTML][HTML] MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer
To identify microRNAs (miRNAs) associated with estrogen receptor (ESR1) status, we
profiled luminal A, ESR1+ breast cancer cell lines versus triple negative (TN), which lack …
profiled luminal A, ESR1+ breast cancer cell lines versus triple negative (TN), which lack …