Unifying the contrasting mechanisms of protein-stabilizing osmolytes
M Mukherjee, J Mondal - The Journal of Physical Chemistry B, 2020 - ACS Publications
The mechanism of protein stabilization by zwitterionic osmolytes has remained a long-
standing puzzle. While osmolytes are prevalently hypothesized to stabilize proteins by …
standing puzzle. While osmolytes are prevalently hypothesized to stabilize proteins by …
Influence of additives on thermoresponsive polymers in aqueous media: a case study of poly (N-isopropylacrylamide)
R Umapathi, PM Reddy, A Rani… - Physical Chemistry …, 2018 - pubs.rsc.org
Thermoresponsive polymers (TRPs) in different solvent media have been studied over a
long period and are important from both scientific and technical points of view. Despite …
long period and are important from both scientific and technical points of view. Despite …
Aqueous mixtures of urea and trimethylamine-N-oxide: Evidence for kosmotropic or chaotropic behavior?
EA Oprzeska-Zingrebe, J Smiatek - The Journal of Physical …, 2019 - ACS Publications
Trimethylamine-N-oxide (TMAO) and urea are commonly produced in many extremophilic
microorganisms that live in harsh environments. In view of high temperature, high pressure …
microorganisms that live in harsh environments. In view of high temperature, high pressure …
Optimized Collective Variable for Collapse Transition in Linear Hydrophobic Polymers: Importance of Hydration Water and End-to-End Distance
Choosing an appropriate collective variable (CV) for any biomolecular process is a
challenging task. Researchers are developing methods to solve this issue using a variety of …
challenging task. Researchers are developing methods to solve this issue using a variety of …
Bottom-up view of the mechanism of action of protein-stabilizing osmolytes
M Mukherjee, J Mondal - The Journal of Physical Chemistry B, 2020 - ACS Publications
The molecular mechanism of osmolytes on the stabilization of native states of protein is still
controversial irrespective of extensive studies over several decades. Recent investigations …
controversial irrespective of extensive studies over several decades. Recent investigations …
Heterogeneous impacts of protein-stabilizing osmolytes on hydrophobic interaction
M Mukherjee, J Mondal - The Journal of Physical Chemistry B, 2018 - ACS Publications
Osmolytes' mechanism of protecting proteins against denaturation is a longstanding puzzle,
further complicated by complex diversities inherent in protein sequences. An emergent …
further complicated by complex diversities inherent in protein sequences. An emergent …
Can an ammonium-based room temperature ionic liquid counteract the urea-induced denaturation of a small peptide?
The folding/unfolding equilibrium of proteins in aqueous medium can be altered by adding
small organic molecules generally termed as co-solvents. Denaturants such as urea are …
small organic molecules generally termed as co-solvents. Denaturants such as urea are …
Hydrophobic association and solvation of neopentane in urea, TMAO and urea–TMAO solutions
A detailed knowledge of hydrophobic association and solvation is crucial for understanding
the con-formational stability of proteins and polymers in osmolyte solutions. Using molecular …
the con-formational stability of proteins and polymers in osmolyte solutions. Using molecular …
Osmolyte-Induced collapse of a charged macromolecule
M Mukherjee, J Mondal - The Journal of Physical Chemistry B, 2019 - ACS Publications
In the recent surge of investigations on osmolyte-induced conformational landscape of
hydrophobic macromolecules notwithstanding, there is a lack of understanding of how the …
hydrophobic macromolecules notwithstanding, there is a lack of understanding of how the …
Surface hydration and preferential interaction directs the charged amino acids-induced changes in protein stability
B Anumalla, NP Prabhu - Journal of Molecular Graphics and Modelling, 2020 - Elsevier
In the present study, we investigate the interaction of amino acid osmolytes, Arg, Lys, Asp
and Glu, and a denaturant, guanidinium chloride (Gdm) with proteins. To achieve this …
and Glu, and a denaturant, guanidinium chloride (Gdm) with proteins. To achieve this …