Skeletal muscle cells possess a unique cellular architecture designed to fulfill their
contractile function. Muscle cells (also known as myofibers) result from the fusion of …

Cardiomyocytes are large (∼ 40,000 µm3), rod-shaped muscle cells that provide the
working force behind each heartbeat. These highly structured cells are packed with dense …

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A/C,
cause Emery–Dreifuss muscular dystrophy, congenital muscular dystrophy and other …

Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue
engineering and regenerative medicine, and are understood to be mechanosensitive to …

The nucleus is the main microtubule-organizing center (MTOC) in muscle cells due to the
accumulation of centrosomal proteins and microtubule (MT) nucleation activity at the nuclear …

Nuclear movements are important for multiple cellular functions, and are driven by polarized
forces generated by motor proteins and the cytoskeleton. During skeletal myofibre formation …

Non-centrosomal microtubule-organizing centres (ncMTOCs) have a variety of roles that are
presumed to serve the diverse functions of the range of cell types in which they are found …

Mutations in LMN A, the gene encoding A-type lamins, cause laminopathies—diseases of
striated muscle and other tissues. The aetiology of laminopathies has been attributed to …

One of the characteristics of eukaryotic cells is their structural plasticity associated with the
ability to carry out a broad range of complex functions, both autonomously and as …

Distinctly organized microtubule networks contribute to the function of differentiated cell
types such as neurons, epithelial cells, skeletal myotubes, and cardiomyocytes. In striated …