Life under the microscope: single-molecule fluorescence highlights the RNA world
The emergence of single-molecule (SM) fluorescence techniques has opened up a vast new
toolbox for exploring the molecular basis of life. The ability to monitor individual …
toolbox for exploring the molecular basis of life. The ability to monitor individual …
Approaches for measuring the dynamics of RNA–protein interactions
RNA–protein interactions are pivotal for the regulation of gene expression from bacteria to
human. RNA–protein interactions are dynamic; they change over biologically relevant …
human. RNA–protein interactions are dynamic; they change over biologically relevant …
Division of labor in an oligomer of the DEAD-box RNA helicase Ded1p
Most aspects of RNA metabolism involve DEAD-box RNA helicases, enzymes that bind and
remodel RNA and RNA-protein complexes in an ATP-dependent manner. Here we show …
remodel RNA and RNA-protein complexes in an ATP-dependent manner. Here we show …
DEAD-box helicases form nucleotide-dependent, long-lived complexes with RNA
F Liu, AA Putnam, E Jankowsky - Biochemistry, 2014 - ACS Publications
DEAD-box RNA helicases bind and remodel RNA and RNA–protein complexes in an ATP-
dependent fashion. Several lines of evidence suggest that DEAD-box RNA helicases can …
dependent fashion. Several lines of evidence suggest that DEAD-box RNA helicases can …
Sen1 has unique structural features grafted on the architecture of the Upf1‐like helicase family
B Leonaitė, Z Han, J Basquin, F Bonneau… - The EMBO …, 2017 - embopress.org
Abstract The superfamily 1B (SF 1B) helicase Sen1 is an essential protein that plays a key
role in the termination of non‐coding transcription in yeast. Here, we identified the~ 90 kDa …
role in the termination of non‐coding transcription in yeast. Here, we identified the~ 90 kDa …
Statistical Mechanics of DNA Unzipping under Periodic Force:<? format?> Scaling Behavior of Hysteresis Loops
S Kumar, G Mishra - Physical review letters, 2013 - APS
A simple model of DNA based on two interacting polymers has been used to study the
unzipping of a double stranded DNA subjected to a periodic force. We propose a dynamical …
unzipping of a double stranded DNA subjected to a periodic force. We propose a dynamical …
Identification and analysis of the interaction network of African swine fever virus D1133L with host proteins
Y Hao, J Yang, B Yang, T Zhang, X Shi… - Frontiers in …, 2022 - frontiersin.org
African swine fever (ASF) is a contagious and lethal hemorrhagic disease in pigs; its spread
results in huge economic losses to the global pig industry. ASF virus (ASFV) is a large …
results in huge economic losses to the global pig industry. ASF virus (ASFV) is a large …
Superfamily II helicases: the potential therapeutic target for cardiovascular diseases
T Fang, X Wang, N Huangfu - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Cardiovascular diseases (CVDs) still maintain high morbidity and mortality globally.
Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic …
Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic …
Helicase-mediated changes in RNA structure at the single-molecule level
SLB König, PS Liyanage, RKO Sigel, D Rueda - RNA biology, 2013 - Taylor & Francis
RNA helicases are a diverse group of RNA-dependent ATPases known to play a large
number of biological roles inside the cell, such as RNA unwinding, remodeling, export and …
number of biological roles inside the cell, such as RNA unwinding, remodeling, export and …
[HTML][HTML] Optical tweezer and TIRF microscopy for single molecule manipulation of RNA/DNA nanostructures including their rubbery property and single molecule …
Life science is often focused on the microscopic level. Single-molecule technology has been
used to observe components at the micro-or nanoscale. Single-molecule imaging provides …
used to observe components at the micro-or nanoscale. Single-molecule imaging provides …