Modulating growth factor receptor signaling to promote corneal epithelial homeostasis

KE Tarvestad-Laise, BP Ceresa - Cells, 2023 - mdpi.com
The corneal epithelium is the first anatomical barrier between the environment and the
cornea; it is critical for proper light refraction onto the retina and prevents pathogens (eg …

FGFR3 alterations in bladder cancer: Sensitivity and resistance to targeted therapies

M Noeraparast, K Krajina, R Pichler… - Cancer …, 2024 - Wiley Online Library
In this review, we revisit the pivotal role of fibroblast growth factor receptor 3 (FGFR3) in
bladder cancer (BLCA), underscoring its prevalence in both non‐muscle‐invasive and …

[HTML][HTML] HER3-targeted therapy: the mechanism of drug resistance and the development of anticancer drugs

H Zeng, W Wang, L Zhang, Z Lin - Cancer Drug Resistance, 2024 - ncbi.nlm.nih.gov
Human epidermal growth factor receptor 3 (HER3), which is part of the HER family, is
aberrantly expressed in various human cancers. Since HER3 only has weak tyrosine kinase …

Crosstalk of growth factor receptors at plasma membrane clathrin-coated sites

MA Alfonzo-Mendez, MP Strub, JW Taraska - bioRxiv, 2024 - biorxiv.org
Cellular communication is regulated at the plasma membrane by the interactions of receptor,
adhesion, signaling, exocytic, and endocytic proteins. Yet, the composition and control of …

[HTML][HTML] Recent Advances in the Importance of Ubiquitylation for Receptor Internalization and Signaling

J Chastel, A Angers - 2024 - intechopen.com
Receptor tyrosine kinases are activated by binding to their ligands, which trigger
modifications in their cytoplasmic domains to initiate signal transduction. Control …