Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

The analgesic properties of exogenous cannabinoids have been recognized for many years
and suggest a regulatory role for the endogenous cannabinoid (“endocannabinoid”) system …

Cannabinoids are antinociceptive in animal models of acute, tissue injury-, and nerve injury-
induced nociception. This review examines the biology of endogenous cannabinoids …

A large body of literature indicates that cannabinoids suppress behavioral responses to
acute and persistent noxious stimulation in animals. This review exax mines …

The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical
allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat …

Cannabis is one of the oldest and widely used substances in the world. Cannabinoids within
the cannabis plant, known as phytocannabinoids, mediate cannabis' effects through …

The analgesic potential of cannabinoids may be hampered by their ability to produce
aversive emotion when administered systemically. We investigated the hypothesis that the …

For centuries, cannabis has been used with many different purposes, including medicinal
use, usually bypassing any formal approval process. However, during the last decade …

Cannabinoid-based medicines have therapeutic potential for the treatment of pain.
Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase …