Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

From the field to the laboratory: Controlling DNA contamination in human ancient DNA research in the high-throughput sequencing era

B Llamas, G Valverde, L Fehren-Schmitz… - STAR: Science & …, 2017 - Taylor & Francis
Abstract High-Throughput DNA Sequencing (HTS) technologies have changed the way in
which we detect and assess DNA contamination in ancient DNA studies. Researchers use …

Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers

M Sikora, A Seguin-Orlando, VC Sousa, A Albrechtsen… - Science, 2017 - science.org
Present-day hunter-gatherers (HGs) live in multilevel social groups essential to sustain a
population structure characterized by limited levels of within-band relatedness and …

Comparative performance of the BGISEQ-500 vs Illumina HiSeq2500 sequencing platforms for palaeogenomic sequencing

SST Mak, S Gopalakrishnan, C Carøe, C Geng… - …, 2017 - academic.oup.com
Ancient DNA research has been revolutionized following development of next-generation
sequencing platforms. Although a number of such platforms have been applied to ancient …

Comparing the performance of three ancient DNA extraction methods for high‐throughput sequencing

C Gamba, K Hanghøj, C Gaunitz… - Molecular Ecology …, 2016 - Wiley Online Library
The DNA molecules that can be extracted from archaeological and palaeontological
remains are often degraded and massively contaminated with environmental microbial …

Evolutionary patterns and processes: lessons from ancient DNA

M Leonardi, P Librado, C Der Sarkissian… - Systematic …, 2017 - academic.oup.com
Ever since its emergence in 1984, the field of ancient DNA has struggled to overcome the
challenges related to the decay of DNA molecules in the fossil record. With the recent …

Experimental conditions improving in‐solution target enrichment for ancient DNA

DI Cruz‐Dávalos, B Llamas, C Gaunitz… - Molecular ecology …, 2017 - Wiley Online Library
High‐throughput sequencing has dramatically fostered ancient DNA research in recent
years. Shotgun sequencing, however, does not necessarily appear as the best‐suited …

A new genus of horse from Pleistocene North America

PD Heintzman, GD Zazula, RDE MacPhee, E Scott… - Elife, 2017 - elifesciences.org
The extinct 'New World stilt-legged', or NWSL, equids constitute a perplexing group of
Pleistocene horses endemic to North America. Their slender distal limb bones resemble …

Human evolution: a tale from ancient genomes

B Llamas, E Willerslev… - … Transactions of the …, 2017 - royalsocietypublishing.org
The field of human ancient DNA (aDNA) has moved from mitochondrial sequencing that
suffered from contamination and provided limited biological insights, to become a fully …

Predicting archaic hominin phenotypes from genomic data

CM Brand, LL Colbran, JA Capra - Annual review of genomics …, 2022 - annualreviews.org
Ancient DNA provides a powerful window into the biology of extant and extinct species,
including humans' closest relatives: Denisovans and Neanderthals. Here, we review what is …