As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …

Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and
adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) …

Glucose transport is rate limiting for dietary glucose utilization by muscle and fat. The
glucose transporter GLUT4 is dynamically sorted and retained intracellularly and …

Insulin, downstream of Akt activation, promotes glucose uptake into fat and muscle cells to
lower postprandial blood glucose, an enforced change in cellular metabolism to maintain …

Background Environmental factors can influence obesity by epigenetic mechanisms.
Adipose tissue plays a key role in obesity-related metabolic dysfunction, and gastric bypass …

Glucose is used aerobically and anaerobically to generate energy for cells. Glucose
transporters (GLUTs) are transmembrane proteins that transport glucose across the cell …

Skeletal muscle is the major tissue disposing of dietary glucose, a function regulated by
insulin-elicited signals that impart mobilization of GLUT4 glucose transporters to the plasma …

Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that
nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. NM1 directly …

Abstract Fibroblast-like synoviocytes (FLSs), play a key role in perpetuating synovial
inflammation and bone erosion in rheumatoid arthritis (RA), however, the underlying …