The zebrafish model is the only available high-throughput vertebrate assessment system,
and it is uniquely suited for studies of in vivo cell biology. A sequenced and annotated …

Morpholino oligonucleotides are the most common anti-sense “knockdown” technique used
in zebrafish (Danio rerio). This review discusses common practices for the design …

Multiple members of the let-7 family of miRNAs are often repressed in human cancers,,
thereby promoting oncogenesis by derepressing targets such as HMGA2, K-Ras and c-Myc …

We have identified an intergenic transcriptional activity that is located between the human
HOXA1 and HOXA2 genes, shows myeloid-specific expression, and is up-regulated during …

Innate immune signalling has an essential role in inflammation, and the dysregulation of
signalling components of this pathway is increasingly being recognised as an important …

The development of facile forward and reverse genetic approaches has propelled the
deconvolution of gene function in biology. While the origins of these techniques reside in the …

Morpholino oligonucleotides (MOs) are an effective, gene-specific antisense knockdown
technology used in many model systems. Here we describe the application of MOs in …

The cross-talk between angiogenesis and immunity within the tumor microenvironment
(TME) is critical for tumor prognosis. While pro-angiogenic and immunosuppressive TME …

Stem cells share the defining characteristics of self-renewal, which maintains or expands the
stem-cell pool, and multi-lineage differentiation, which generates and regenerates tissues …

MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias.
Development of effective treatments has been impeded by limited insight into pathogenic …