The senescence-associated secretory phenotype and its physiological and pathological implications

B Wang, J Han, JH Elisseeff, M Demaria - Nature Reviews Molecular …, 2024 - nature.com
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

Immunoengineering biomaterials for musculoskeletal tissue repair across lifespan

J Han, AN Rindone, JH Elisseeff - Advanced Materials, 2024 - Wiley Online Library
Musculoskeletal diseases and injuries are among the leading causes of pain and morbidity
worldwide. Broad efforts have focused on developing pro‐regenerative biomaterials to treat …

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

J Aguado, AA Amarilla, A Taherian Fard, EA Albornoz… - Nature aging, 2023 - nature.com
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …

Developing transcriptomic signatures as a biomarker of cellular senescence

S Mahmud, LE Pitcher, E Torbenson… - Ageing Research …, 2024 - Elsevier
Cellular senescence is a cell fate driven by different types of stress, where damaged cells
exit from the cell cycle and, in many cases, develop an inflammatory senescence-associated …

“Bone-SASP” in skeletal aging

CL Fang, B Liu, M Wan - Calcified Tissue International, 2023 - Springer
Senescence is a complex cell state characterized by stable cell cycle arrest and a unique
secretory pattern known as the senescence-associated secretory phenotype (SASP). The …

A nutrigeroscience approach: Dietary macronutrients and cellular senescence

MF Calubag, PD Robbins, DW Lamming - Cell Metabolism, 2024 - cell.com
Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is
one of the hallmarks of aging. Senescence and the senescence-associated secretory …

[HTML][HTML] Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

Q Yu, HE Walters, G Pasquini, SP Singh, M Lachnit… - Developmental cell, 2023 - cell.com
Axolotl limb regeneration is accompanied by the transient induction of cellular senescence
within the blastema, the structure that nucleates regeneration. The precise role of this …

Age‐associated Senescent–T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response

J Han, C Cherry, JC Mejías, K Krishnan… - Advanced …, 2024 - Wiley Online Library
Aging is associated with immunological changes that compromise response to infections
and vaccines, exacerbate inflammatory diseases and can potentially mitigate tissue repair …

SenNet recommendations for detecting senescent cells in different tissues

V Suryadevara, AD Hudgins, A Rajesh… - … Reviews Molecular Cell …, 2024 - nature.com
Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …