The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions
A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …
Immunoengineering biomaterials for musculoskeletal tissue repair across lifespan
Musculoskeletal diseases and injuries are among the leading causes of pain and morbidity
worldwide. Broad efforts have focused on developing pro‐regenerative biomaterials to treat …
worldwide. Broad efforts have focused on developing pro‐regenerative biomaterials to treat …
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
Developing transcriptomic signatures as a biomarker of cellular senescence
S Mahmud, LE Pitcher, E Torbenson… - Ageing Research …, 2024 - Elsevier
Cellular senescence is a cell fate driven by different types of stress, where damaged cells
exit from the cell cycle and, in many cases, develop an inflammatory senescence-associated …
exit from the cell cycle and, in many cases, develop an inflammatory senescence-associated …
“Bone-SASP” in skeletal aging
CL Fang, B Liu, M Wan - Calcified Tissue International, 2023 - Springer
Senescence is a complex cell state characterized by stable cell cycle arrest and a unique
secretory pattern known as the senescence-associated secretory phenotype (SASP). The …
secretory pattern known as the senescence-associated secretory phenotype (SASP). The …
A nutrigeroscience approach: Dietary macronutrients and cellular senescence
MF Calubag, PD Robbins, DW Lamming - Cell Metabolism, 2024 - cell.com
Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is
one of the hallmarks of aging. Senescence and the senescence-associated secretory …
one of the hallmarks of aging. Senescence and the senescence-associated secretory …
[HTML][HTML] Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Q Yu, HE Walters, G Pasquini, SP Singh, M Lachnit… - Developmental cell, 2023 - cell.com
Axolotl limb regeneration is accompanied by the transient induction of cellular senescence
within the blastema, the structure that nucleates regeneration. The precise role of this …
within the blastema, the structure that nucleates regeneration. The precise role of this …
Age‐associated Senescent–T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response
Aging is associated with immunological changes that compromise response to infections
and vaccines, exacerbate inflammatory diseases and can potentially mitigate tissue repair …
and vaccines, exacerbate inflammatory diseases and can potentially mitigate tissue repair …
SenNet recommendations for detecting senescent cells in different tissues
Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …
linked to various biological processes with both beneficial and detrimental roles in humans …