Facilitation of sensory transmission to motoneurons during cortical or sensory‐evoked primary afferent depolarization (PAD) in humans

K Metz, IC Matos, Y Li, B Afsharipour… - The Journal of …, 2023 - Wiley Online Library
Sensory and corticospinal tract (CST) pathways activate spinal GABAergic interneurons that
have axoaxonic connections onto proprioceptive (Ia) afferents that cause long‐lasting …

Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons

S Lin, K Hari, S Black, A Khatmi… - Journal of …, 2023 - journals.physiology.org
When a muscle is stretched, sensory feedback not only causes reflexes but also leads to a
depolarization of sensory afferents throughout the spinal cord (primary afferent …

Effect of muscle length on the modulation of H-reflex and inhibitory mechanisms of Ia afferent discharges during passive muscle lengthening

J Colard, M Jubeau, M Crouzier… - Journal of …, 2024 - journals.physiology.org
The effectiveness of activated Ia afferents to discharge α-motoneurons is decreased during
passive muscle lengthening compared with static and shortening muscle conditions …

Post-activation depression of the Hoffman reflex is not altered by galvanic vestibular stimulation in healthy subjects

MC Alvarado-Navarrete, AC Pliego-Carrillo… - Frontiers in Integrative …, 2023 - frontiersin.org
The comprehension of the neural elements interacting in the spinal cord affected by
vestibular input will contribute to the understanding of movement execution in normal and …

GABA Increases Sensory Transmission In Monkeys

AA Mahrous, L Liang, JM Balaguer, JC Ho, K Hari… - bioRxiv, 2023 - biorxiv.org
Sensory input flow is central to voluntary movements. For almost a century, GABA was
believed to modulate this flow by inhibiting sensory axons in the spinal cord to sculpt neural …

Has the importance of GABAA presynaptic inhibition been overestimated in human motor control?

D Burke - Journal of Physiology, 2023 - search.ebscohost.com
The reflex depression was accompanied by a decrease in motoneuron firing rate,
interpreted as evidence of postsynaptic inhibition of the motoneuron. Voluntary contraction …

[HTML][HTML] Potentiation of cortico-spinal output via targeted electrical stimulation of the motor thalamus

JC Ho, EM Grigsby, A Damiani, L Liang… - Nature …, 2024 - nature.com
Cerebral white matter lesions prevent cortico-spinal descending inputs from effectively
activating spinal motoneurons, leading to loss of motor control. However, in most cases, the …