Only a small fraction of individuals exposed to Mycobacterium tuberculosis develop clinical
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder of
phagocytic cells resulting in failure to kill a characteristic spectrum of bacteria and fungi and …

An essential guide to this major contemporary issue, Consanguinity in Context is a uniquely
comprehensive account of intra-familial marriage. Detailed information on past and present …

Disseminated disease in children and pulmonary disease in adults constitute two major
epidemiological and clinical forms of tuberculosis. Paradoxically, only a small fraction of …

Primary immunodeficiency diseases (PIDs) are a group of inherited disorders, characterized
by defects of the immune system predisposing individuals to variety of manifestations …

Background Bacillus Calmette-Guérin (BCG) vaccine is a live attenuated bacterial vaccine
derived from Mycobacterium bovis, which is mostly administered to neonates in regions …

Purpose Chronic granulomatous disease (CGD) is a primary immunodeficiency
characterized by an inability of phagocytes to produce reactive oxygen species, impairing …

Infection of humans with M ycobacterium tuberculosis remains frequent and may still lead to
death. After primary infection, the immune system is often able to control M. tuberculosis …

Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent
and intense exposure. These persons do not exhibit adaptive immune priming as measured …

Primary immunodeficiency disorders (PID) are a heterogeneous group of diseases,
characterized by an increased susceptibility to infections. A total of 930 patients (573 males …