General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of
the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase …

Simple Summary Urinary bladder cancer is one of the ten major cancers worldwide, with
higher incidences in males, in smokers, and in highly industrialized countries. New …

Accumulating evidence highlights the role of histone acetyltransferase GCN5 in the
regulation of cell metabolism in metazoans. Here, we report that GCN5 is a negative …

Alternative lengthening of telomeres (ALT) supports telomere maintenance in 10–15% of
cancers, thus representing a compelling target for therapy. By performing anti-cancer …

General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-
associated factor (PCAF), are lysine acetyltransferases that modify both histone and non …

Lung cancer causes the highest mortality in cancer-related deaths. As these cancers often
become resistant to existing therapies, definition of novel molecular targets is needed …

Lysine acetylation is a critical post-translation modification that can impact a protein's
localization, stability, and function. Originally thought to only occur on histones, we now …

Recent evidence suggests that the presence of more than one pathogenic mutation in a
single patient is more common than previously anticipated. One of the challenges hereby is …

Some cancer cells elongate their telomeres through the ALT (alternative lengthening of
telomeres) pathway, which is based on homologous recombination for the addition of …

Histone modification is critical for the process of autophagy in osteosarcoma. Whether
phosphorylated histone H4 (H4) mediates autophagy remains to be seen. Here, we aimed to …