Combining hypothesis-and data-driven neuroscience modeling in FAIR workflows
Modeling in neuroscience occurs at the intersection of different points of view and
approaches. Typically, hypothesis-driven modeling brings a question into focus so that a …
approaches. Typically, hypothesis-driven modeling brings a question into focus so that a …
Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions
We demonstrate a combined experimental and computational approach for the quantitative
characterization of lateral interactions between membrane-associated proteins. In particular …
characterization of lateral interactions between membrane-associated proteins. In particular …
Contextualizing protein representations using deep learning on protein networks and single-cell data
Understanding protein function and developing molecular therapies require deciphering the
cell types in which proteins act as well as the interactions between proteins. However …
cell types in which proteins act as well as the interactions between proteins. However …
Sequence-defined macrocycles for understanding and controlling the build-up of hierarchical order in self-assembled 2D arrays
JR Dobscha, HD Castillo, Y Li, RE Fadler… - Journal of the …, 2019 - ACS Publications
Anfinsen's dogma that sequence dictates structure is fundamental to understanding the
activity and assembly of proteins. This idea has been applied to all manner of oligomers but …
activity and assembly of proteins. This idea has been applied to all manner of oligomers but …
Surface plasmon resonance study of interaction between lactoferrin and naringin
Lactoferrin (LF) is a glycoprotein that serves as a potential vehicle for small bioactive
molecules in food. In an effort to improve this functionality, the kinetic and thermodynamic …
molecules in food. In an effort to improve this functionality, the kinetic and thermodynamic …
Understanding the functional role of membrane confinements in TNF-mediated signaling by multiscale simulations
The interaction between TNFα and TNFR1 is essential in maintaining tissue development
and immune responses. While TNFR1 is a cell surface receptor, TNFα exists in both soluble …
and immune responses. While TNFR1 is a cell surface receptor, TNFα exists in both soluble …
Computational studies of protein–protein dissociation by statistical potential and coarse-grained simulations: A case study on interactions between colicin E9 …
Proteins carry out their diverse functions in cells by forming interactions with each other. The
dynamics of these interactions are quantified by the measurement of association and …
dynamics of these interactions are quantified by the measurement of association and …
A computational model for understanding the oligomerization mechanisms of TNF receptor superfamily
By recognizing members in the tumor necrosis factor (TNF) receptor superfamily, TNF ligand
proteins function as extracellular cytokines to activate various signaling pathways involved …
proteins function as extracellular cytokines to activate various signaling pathways involved …
[HTML][HTML] A multiscale study on the mechanisms of spatial organization in ligand-receptor interactions on cell surfaces
The binding of cell surface receptors with extracellular ligands triggers distinctive signaling
pathways, leading into the corresponding phenotypic variation of cells. It has been found …
pathways, leading into the corresponding phenotypic variation of cells. It has been found …
A multiscale model for the self-assembly of coat proteins in bacteriophage MS2
The self-assembly of viral capsids is an essential step to the formation of infectious viruses.
Elucidating the kinetic mechanisms of how a capsid or virus-like particle assembles could …
Elucidating the kinetic mechanisms of how a capsid or virus-like particle assembles could …