The role of indoleamine 2, 3-dioxygenase in immune suppression and autoimmunity

JC Mbongue, DA Nicholas, TW Torrez, NS Kim… - Vaccines, 2015 - mdpi.com
Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the
degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole …

Pseudomonas Exotoxin A: optimized by evolution for effective killing

M Michalska, P Wolf - Frontiers in microbiology, 2015 - frontiersin.org
Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium
Pseudomonas aeruginosa. This review describes current knowledge about the intoxication …

Bacteria-Host Crosstalk: Sensing of the Quorum in the Context of Pseudomonas aeruginosa Infections

MV Turkina, E Vikström - Journal of innate immunity, 2019 - karger.com
Cell-to-cell signaling via small molecules is an essential process to coordinate behavior in
single species within a community, and also across kingdoms. In this review, we discuss the …

Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses

SJ Wood, JW Goldufsky, MY Seu, AH Dorafshar… - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is one of the most virulent opportunistic Gram-negative bacterial
pathogens in humans. It causes many acute and chronic infections with morbidity and …

Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin

SM Havaei, MG Aucoin… - Frontiers in …, 2021 - frontiersin.org
Cancer is one of the prominent causes of death worldwide. Despite the existence of various
modalities for cancer treatment, many types of cancer remain uncured or develop resistance …

Oral delivery of protein drugs bioencapsulated in plant cells

KC Kwon, H Daniell - Molecular Therapy, 2016 - cell.com
Plants cells are now approved by the FDA for cost-effective production of protein drugs
(PDs) in large-scale current Good Manufacturing Practice (cGMP) hydroponic growth …

The role of dendritic cells in tissue‐specific autoimmunity

J Mbongue, D Nicholas, A Firek… - Journal of immunology …, 2014 - Wiley Online Library
In this review, we explore the role of dendritic cell subsets in the development of tissue‐
specific autoimmune diseases. From the increasing list of dendritic cell subclasses, it is …

A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death

F Rosato, R Pasupuleti, J Tomisch… - Journal of Translational …, 2022 - Springer
Background Aberrant glycosylation patterns play a crucial role in the development of cancer
cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate …

New Corynebacterium Species with the Potential to Produce Diphtheria Toxin

M Prygiel, M Polak, E Mosiej, K Wdowiak, K Formińska… - Pathogens, 2022 - mdpi.com
Only three Corynebacterium species are known to produce a lethal exotoxin called
diphtheria toxin. These are C. diphtheriae, C. ulcerans and C. pseudotuberculosis. The …

Functional Diversity of Novel Lectins with Unique Structural Features in Marine Animals

T Hatakeyama, H Unno - Cells, 2023 - mdpi.com
Due to their remarkable structural diversity, glycans play important roles as recognition
molecules on cell surfaces of living organisms. Carbohydrates exist in numerous isomeric …