The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively
in the lateral hypothalamus. They act on two specific receptors that are widely distributed …

Alcohol use disorder remains a substantial social, health, and economic problem and
problem drinking levels in women have been increasing in recent years. Understanding …

In the late 1930s and early 1940s, it was discovered that the substitution on aromatic rings of
hydrogen atoms with chlorine yielded a novel chemistry of antimicrobials. However, within a …

Orexins comprise two neuropeptides produced by orexin neurons in the lateral
hypothalamus and are released by extensive projections of these neurons throughout the …

Tailor-made AAs are indispensable components of modern medicinal chemistry and are
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …

Orexins are neuropeptides that activate the rhodopsin-like G protein-coupled receptors
OX1R and OX2R. The orexin system plays an important role in the regulation of the sleep …

As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD)
treatments could not be more urgent. Two separate hypothalamic neuropeptide systems …

The neuropeptide hypocretin/orexin plays a broad and important role in physiological
functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and …

Orexin, also known as hypocretin, is an excitatory neuropeptide secreted by the
hypothalamus. Orexin is divided into orexin-A (OXA) and orexin-B (OXB), which are derived …

Orexin is a neuropeptide secreted from lateral hypothalamus and pre-frontal cortex
concerned in the wakefulness and excitement. This study aimed to review the possible …