Although the root cause of sickle cell disease is the polymerization of hemoglobin S (HbS) to
form fibers that make red cells less flexible, most drugs currently being assessed in clinical …

The hallmark of sickle cell disease is the polymerization of sickle haemoglobin due to a point
mutation in the β‐globin gene (HBB). Under low oxygen saturation, sickle haemoglobin …

Polymerization of deoxygenated hemoglobin S underlies the pathophysiology of sickle cell
disease (SCD). In activating red blood cell pyruvate kinase and glycolysis, mitapivat (AG …

Hypoxia can act as an initial trigger to induce erythrocyte sickling and eventual end organ
damage in sickle cell disease (SCD). Many factors and metabolites are altered in response …

Stem cell transplantation and genetic therapies offer potential cures for patients with sickle
cell disease (SCD), but these options require advanced medical facilities and are expensive …

The erythrocytes in sickle cell disease have long been known to show decreased oxygen
affinity compared with those from healthy volunteers. 1–4 This property is measured as an …

Sickle cell disease is caused by a mutation in the β-globin chain of the haemoglobin
molecule. Sickle haemoglobin, the result of this mutation, has the singular property of …

Recent interest in therapies for sickle cell anemia based on elevating fetal Hb has made
accurate estimates of the sparing effect of fetal Hb (Hb F) and other non-sickle Hbs on sickle …

The primary pathophysiological event in the erythrocytes of individuals with the various
sickle syndromes is the intracellular aggregation or polymerization of sickle haemoglobin …

The pathology of sickle cell disease is caused by polymerization of the abnormal
hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to …