Bacterial growth and cell division: a mycobacterial perspective

EC Hett, EJ Rubin - Microbiology and Molecular Biology Reviews, 2008 - Am Soc Microbiol
The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

Gaseous O2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors

T Shimizu, D Huang, F Yan, M Stranava… - Chemical …, 2015 - ACS Publications
The heme iron complex is one of the most important cofactors in biological systems (Figure
1). The major functions of the heme iron complex are to serve as the O2 binding site for …

[图书][B] Handbook Of Porphyrin Science: With Applications To Chemistry, Physics, Materials Science, Engineering, Biology And Medicine (Volumes 6-10)

KM Kadish, R Guilard, KM Smith - 2010 - books.google.com
This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence

H Zheng, CJ Colvin, BK Johnson, PD Kirchhoff… - Nature chemical …, 2017 - nature.com
Abstract The Mycobacterium tuberculosis (Mtb) DosRST two-component regulatory system
promotes the survival of Mtb during non-replicating persistence (NRP). NRP bacteria help …

Redox homeostasis in mycobacteria: the key to tuberculosis control?

A Kumar, A Farhana, L Guidry, V Saini… - Expert reviews in …, 2011 - cambridge.org
Mycobacterium tuberculosis (Mtb) is a metabolically flexible pathogen that has the
extraordinary ability to sense and adapt to the continuously changing host environment …

Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon

A Kumar, JS Deshane, DK Crossman… - Journal of biological …, 2008 - ASBMB
The mechanisms that allow Mycobacterium tuberculosis (Mtb) to persist in human tissue for
decades and to then abruptly cause disease are not clearly understood. Regulatory …

Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection

MU Shiloh, P Manzanillo, JS Cox - Cell host & microbe, 2008 - cell.com
Mycobacterium tuberculosis (MTB) expresses a set of genes known as the dormancy
regulon in vivo. These genes are expressed in vitro in response to nitric oxide (NO) or …

Adaptation to environmental stimuli within the host: two-component signal transduction systems of Mycobacterium tuberculosis

DJ Bretl, C Demetriadou, TC Zahrt - Microbiology and molecular …, 2011 - Am Soc Microbiol
Pathogenic microorganisms encounter a variety of environmental stresses following
infection of their respective hosts. Mycobacterium tuberculosis, the etiological agent of …

Heme sensor proteins

HM Girvan, AW Munro - Journal of Biological Chemistry, 2013 - ASBMB
Heme is a prosthetic group best known for roles in oxygen transport, oxidative catalysis, and
respiratory electron transport. Recent years have seen the roles of heme extended to …

Mycobacterium tuberculosis Transcriptional Adaptation, Growth Arrest and Dormancy Phenotype Development Is Triggered by Vitamin C

NK Taneja, S Dhingra, A Mittal, M Naresh, JS Tyagi - PloS one, 2010 - journals.plos.org
Background Tubercle bacilli are thought to persist in a dormant state during latent
tuberculosis (TB) infection. Although little is known about the host factors that induce and …