Ischaemic stroke

BCV Campbell, DA De Silva, MR Macleod… - Nature reviews Disease …, 2019 - nature.com
Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …

Gut microbiota–derived short-chain fatty acids promote poststroke recovery in aged mice

J Lee, J d'Aigle, L Atadja, V Quaicoe… - Circulation …, 2020 - Am Heart Assoc
Rationale: The elderly experience profound systemic responses after stroke, which
contribute to higher mortality and more severe long-term disability. Recent studies have …

Gut microbiota and their metabolites in stroke: a double-edged sword

A Peh, JA O'Donnell, BRS Broughton, FZ Marques - Stroke, 2022 - Am Heart Assoc
Besides damaging the brain, stroke causes systemic changes, including to the
gastrointestinal system. A growing body of evidence supports the role of the gut and its …

The influence of gut dysbiosis in the pathogenesis and management of ischemic stroke

SB Chidambaram, AG Rathipriya, AM Mahalakshmi… - Cells, 2022 - mdpi.com
Recent research on the gut microbiome has revealed the influence of gut microbiota (GM)
on ischemic stroke pathogenesis and treatment outcomes. Alterations in the diversity …

Brain–heart interaction: cardiac complications after stroke

Z Chen, P Venkat, D Seyfried, M Chopp, T Yan… - Circulation …, 2017 - Am Heart Assoc
Neurocardiology is an emerging specialty that addresses the interaction between the brain
and the heart, that is, the effects of cardiac injury on the brain and the effects of brain injury …

Age‐related changes in the gut microbiota influence systemic inflammation and stroke outcome

MS Spychala, VR Venna, M Jandzinski… - Annals of …, 2018 - Wiley Online Library
Objective Chronic systemic inflammation contributes to the pathogenesis of many age‐
related diseases. Although not well understood, alterations in the gut microbiota, or …

Aging microbiota-gut-brain axis in stroke risk and outcome

P Honarpisheh, RM Bryan, LD McCullough - Circulation research, 2022 - Am Heart Assoc
The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …

Role of endogenous lipopolysaccharides in neurological disorders

M Kalyan, AH Tousif, S Sonali, C Vichitra, T Sunanda… - Cells, 2022 - mdpi.com
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …

Microbial peer pressure: the role of the gut microbiota in hypertension and its complications

RR Muralitharan, HA Jama, L Xie, A Peh, M Snelson… - …, 2020 - Am Heart Assoc
There is increasing evidence of the influence of the gut microbiota on hypertension and its
complications, such as chronic kidney disease, stroke, heart failure, and myocardial …