Natural products: a continuing source of novel drug leads
GM Cragg, DJ Newman - Biochimica et Biophysica Acta (BBA)-General …, 2013 - Elsevier
BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …
useful drugs developed from plant sources. Following discovery of the penicillins, drug …
Catharanthus roseus (L.) G. Don: A review of its ethnobotany, phytochemistry, ethnopharmacology and toxicities
Ethnopharmacological relevance Catharanthus roseus (L.) G. Don is a well known
medicinal plant belonging to family Apocynaceae that have been traditionally used as …
medicinal plant belonging to family Apocynaceae that have been traditionally used as …
Single-cell multi-omics in the medicinal plant Catharanthus roseus
Advances in omics technologies now permit the generation of highly contiguous genome
assemblies, detection of transcripts and metabolites at the level of single cells and high …
assemblies, detection of transcripts and metabolites at the level of single cells and high …
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle
Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …
Mining the biodiversity of plants: a revolution in the making
Only a small fraction of the immense diversity of plant metabolism has been explored for the
production of new medicines and other products important to human well-being. The …
production of new medicines and other products important to human well-being. The …
A sustainable synthesis of green carbon quantum dot (CQD) from Catharanthus roseus (white flowering plant) leaves and investigation of its dual fluorescence …
T Arumugham, M Alagumuthu, RG Amimodu… - Sustainable Materials …, 2020 - Elsevier
In this work, we have presented a facile, efficient and green strategy to prepare fluorescence
CQD for multi ion sensing and bio imaging application. Hydrothermal carbonization …
CQD for multi ion sensing and bio imaging application. Hydrothermal carbonization …
An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis
The iridoids comprise a large family of distinctive bicyclic monoterpenes that possess a wide
range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and …
range of pharmacological activities, including anticancer, anti-inflammatory, antifungal and …
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast
Y Qu, MLAE Easson, J Froese… - Proceedings of the …, 2015 - National Acad Sciences
Antitumor substances related to vinblastine and vincristine are exclusively found in the
Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family …
Catharanthus roseus (Madagascar periwinkle), a member of the Apocynaceae plant family …
A century of studying plant secondary metabolism—from “what?” to “where, how, and why?”
RA Dixon, AJ Dickinson - Plant Physiology, 2024 - academic.oup.com
Over the past century, early advances in understanding the identity of the chemicals that
collectively form a living plant have led scientists to deeper investigations exploring where …
collectively form a living plant have led scientists to deeper investigations exploring where …
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
A Van Moerkercke, P Steensma… - Proceedings of the …, 2015 - National Acad Sciences
Plants make specialized bioactive metabolites to defend themselves against attackers. The
conserved control mechanisms are based on transcriptional activation of the respective …
conserved control mechanisms are based on transcriptional activation of the respective …