There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …

The unprecedented rate of extinction calls for efficient use of genetics to help conserve
biodiversity. Several recent genomic and simulation-based studies have argued that the …

In cases of severe wildlife population decline, a key question is whether recovery efforts will
be impeded by genetic factors, such as inbreeding depression. Decades of excess mortality …

The observation that small isolated populations often suffer reduced fitness from inbreeding
depression has guided conservation theory and practice for decades. However …

Examining complete gene knockouts within a viable organism can inform on gene function.
We sequenced the exomes of 3222 British adults of Pakistani heritage with high parental …

The Out-of-Africa (OOA) dispersal∼ 50,000 y ago is characterized by a series of founder
events as modern humans expanded into multiple continents. Population genetics theory …

Efforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly
involve the use of next-generation sequencing and comparative genomic hybridization …

Mammalian species carry~ 100 loss-of-function variants per individual,, where~ 1–5 of these
impact essential genes and cause embryonic lethality or severe disease when homozygous …

Drug repurposing has attracted increased attention, especially in the context of drug
discovery rates that remain too low despite a recent wave of approvals for biological …